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Biophilia wave neuromodulation for the management of osteoarthritis pain: a real word evidence study

Introduction
Managing osteoarthritis aims to relieve pain, improve joint function and quality of life. Current guidelines recommend combining non-drug and pharmacological approaches. A non-medication solution integrating an endorphin-stimulating Biophilia wave device, mobile application, and coaching program was evaluated.

Methods
This combined approach is evaluated in a real-world evidence study over three months in patients with osteoarthritis-related pain. The primary endpoint was patient-perceived change at three months using the Patient Global Impression of Change (PGIC). Secondary outcomes, assessed at baseline and three months, included pain intensity (mean and maximum), frequency of pain crises, quality of life, sleep, mental health, and medication use.

Results
Among 156 participants completing follow-up, 80.1% reported improvement (PGIC > 4). Quality of life improved by 29.8%, while sleep and mental health improved by 13.1% and 13.5%, respectively. Mean and maximum pain intensity decreased by 33.9% and 33.1%. Pain crises became less frequent, and patients reported reduced medication use.

Conclusion
These results align with recent randomized controlled trial findings, supporting Biophilia millimeter wave neuromodulation as an innovative, non-drug strategy targeting both nociceptive and nociplastic pain mechanisms to improve quality of life in osteoarthritis patients.

Plain Language Summary
Osteoarthritis causes joint pain and limits daily activities. Its treatment focuses on reducing pain, improving movement, and enhancing quality of life. Current recommendations suggest combining lifestyle changes with medication. This study evaluated a Biophilia millimeter wave device that stimulates natural endorphins, a mobile app, and a coaching program, used for three months by people with osteoarthritis pain. After three months, 80% of participants reported feeling better. Pain levels decreased by about one-third, and quality of life improved by nearly 30%. Sleep, mood, and daily comfort also improved, and many participants reported using less medication. These findings suggest that Biophilia millimeter wave therapy is a promising, non-drug approach that may help people with osteoarthritis manage pain and improve their well-being.